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mitotane will decrease the extent or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.Cell proliferation was assessed using a bromodeoxyuridine (BrdU) proliferatio